Anumantha G Kanthasamy Selected Research

Ubiquitin

8/2009	Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63.
12/2008	Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation.
6/2007	Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease.
9/2006	Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models.

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Anumantha G Kanthasamy Research Topics

Disease

56	Parkinson Disease (Parkinson's Disease) 01/2024 - 03/2003
18	Mitochondrial Diseases (Mitochondrial Disease) 01/2024 - 08/2005
18	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023 - 03/2003
13	Inflammation (Inflammations) 01/2022 - 11/2009
11	Neuroinflammatory Diseases 01/2023 - 04/2012
6	Synucleinopathies 01/2023 - 07/2017
6	Scrapie 01/2020 - 09/2006
6	Prion Diseases (Transmissible Spongiform Encephalopathies) 11/2017 - 09/2006
4	Parkinsonian Disorders (Parkinsonism) 01/2021 - 07/2017
3	Dementia (Dementias) 01/2023 - 01/2019
3	Traumatic Brain Injuries (Traumatic Brain Injury) 09/2022 - 07/2017
3	Nervous System Diseases (Neurological Disorders) 01/2018 - 04/2005
2	Lewy Body Disease (Lewy Body Dementia) 01/2021 - 01/2020
2	Wounds and Injuries (Trauma) 10/2020 - 07/2017
2	Gliosis 01/2019 - 01/2018
2	Seizures (Absence Seizure) 01/2018 - 01/2018
2	Anosmia 11/2014 - 07/2014
1	Pain (Aches) 11/2023
1	Neoplasms (Cancer) 11/2023
1	Dysbiosis 01/2022
1	Pneumonia (Pneumonitis) 06/2021
1	Bites and Stings (Sting) 05/2021
1	Endotoxemia 08/2020
1	Vector Borne Diseases 01/2019
1	Alzheimer Disease (Alzheimer's Disease) 01/2019
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2019
1	Pathologic Processes 01/2019
1	Dystonia (Limb Dystonia) 01/2019
1	Hypoxia (Hypoxemia) 01/2018
1	Status Epilepticus (Complex Partial Status Epilepticus) 01/2018

Drug/Important Bio-Agent (IBA)

21	Proteins (Proteins, Gene)FDA Link 01/2023 - 08/2005
12	SynucleinsIBA 09/2022 - 02/2011
12	Phosphotransferases (Kinase)IBA 01/2021 - 08/2005
12	ManganeseIBA 12/2019 - 04/2005
7	acetovanillone (apocynin)IBA 01/2021 - 10/2012
7	Protein Kinases (Protein Kinase)IBA 01/2016 - 11/2006
6	InflammasomesIBA 01/2021 - 01/2017
6	IronIBA 06/2018 - 09/2006
5	alpha-SynucleinIBA 01/2023 - 09/2005
5	Protein Kinase C-deltaIBA 01/2021 - 08/2005
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 04/2015
5	PrionsIBA 01/2020 - 09/2006
5	MetalsIBA 12/2019 - 06/2010
5	AntioxidantsIBA 01/2018 - 09/2006
4	Neuroprotective AgentsIBA 01/2022 - 09/2007
4	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2021 - 03/2002
4	EnzymesIBA 01/2021 - 11/2009
4	Prion ProteinsIBA 11/2017 - 09/2006
4	UbiquitinIBA 08/2009 - 09/2006
4	Proteasome Endopeptidase Complex (Proteasome)IBA 08/2009 - 09/2006
3	Protein AggregatesIBA 01/2023 - 10/2011
3	CytokinesIBA 01/2021 - 11/2009
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2020 - 04/2012
3	MicroRNAs (MicroRNA)IBA 01/2019 - 01/2017
3	Dopamine (Intropin)FDA LinkGeneric 01/2019 - 09/2006
3	diapocyninIBA 11/2014 - 10/2012
2	Metformin (Glucophage)FDA LinkGeneric 01/2024 - 01/2022
2	Histones (Histone)IBA 01/2023 - 12/2014
2	Formaldehyde (Formol)FDA Link 01/2023 - 01/2020
2	PesticidesIBA 01/2022 - 01/2019
2	RotenoneIBA 01/2022 - 01/2017
2	Small Interfering RNA (siRNA)IBA 05/2021 - 01/2019
2	Cytochromes c (Cytochrome c)IBA 05/2021 - 03/2002
2	src-Family KinasesIBA 08/2020 - 01/2018
2	Retinaldehyde (Retinal)IBA 01/2019 - 07/2017
2	Transcription Factors (Transcription Factor)IBA 01/2019 - 11/2009
2	HepcidinsIBA 06/2018 - 01/2016
2	Kainic Acid (Kainate)IBA 01/2018 - 01/2018
2	Protein Kinase CIBA 01/2017 - 09/2007
2	Leucine (L-Leucine)FDA Link 11/2014 - 08/2013
2	Divalent CationsIBA 01/2014 - 09/2006
2	Protein Isoforms (Isoforms)IBA 10/2011 - 09/2007
2	NeurotoxinsIBA 10/2008 - 06/2007
2	DieldrinIBA 10/2008 - 08/2005
2	Caspase 3 (Caspase-3)IBA 11/2006 - 03/2002
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2023
1	Heavy MetalsIBA 09/2022
1	HerbicidesIBA 09/2022
1	Pathogen-Associated Molecular Pattern MoleculesIBA 06/2021
1	DNA (Deoxyribonucleic Acid)IBA 05/2021
1	Particulate MatterIBA 05/2021
1	Inositol (Myoinositol)IBA 01/2021
1	EndoribonucleasesIBA 01/2021
1	Tyrosine (L-Tyrosine)FDA Link 01/2021
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2021
1	Activating Transcription Factor 4IBA 01/2021
1	Eukaryotic Initiation Factor-2 (EIF 2)IBA 01/2021
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2021
1	salubrinalIBA 01/2021
1	NeuropeptidesIBA 10/2020
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 08/2020
1	Interleukin-6 (Interleukin 6)IBA 08/2020
1	AntibodiesIBA 02/2020
1	ParaffinIBA 01/2020
1	ethyl pyruvateIBA 01/2019
1	HMGB1 Protein (HMG1)IBA 01/2019
1	saracatinibIBA 01/2018
1	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 11/2017

Therapy/Procedure

2	Therapeutics 04/2015 - 08/2014
1	Behavior Control 01/2018